1
World
Proposal to Protect Antarctic Waters Is Scaled Back
A proposal by the United States and New Zealand to create a huge ocean reserve in Antarctic waters has been sharply reduced after opposition from Russia and other nations with large fishing industries.
2
U.S.
Imagining a Cyberattack on the Power Grid
A former North Dakota senator, Byron L. Dorgan, has written a book that he hopes will get people to think about the electricity sector’s vulnerability.
3
Business Day
Find the Loan Behind the Loans
When regulators accuse financial firms of predatory lending, shouldn’t they track down where these firms are getting their capital?
4
Opinion
New York City Primary Choices
The Times made recommendations in some of the most contested races, including mayor, public advocate and comptroller.| Democrats | Pct. | |
|---|---|---|
| de Blasio | 40.2% | |
| Thompson | 26.1 | |
| Quinn | 15.5 | |
| Liu | 7.0 | |
| Weiner | 4.9 | |
| 97% reporting | ||
|
If no candidate gets at least 40 percent of the vote, a runoff is held with the top two
| ||
De Blasio Has Wide Lead in Primary
Needs 40 Percent to Avoid Runoff; Lhota Wins G.O.P. Primary
By DAVID M. HALBFINGER and DAVID W. CHEN
Bill de Blasio captured far more votes than his rivals in the Democratic
mayoral primary, and Joseph J. Lhota won the Republican primary.
Spitzer Loses in His Bid for Comptroller
By KATE TAYLOR
Scott M. Stringer foiled Eliot Spitzer’s attempted political comeback in their primary.
Latest Updates
N.Y.C. Primary Results »
| Democrats | Pct. | |
|---|---|---|
| Stringer | 52.2% | |
| Spitzer | 47.8 | |
| 97% reporting | ||
|
| ||
5
World
Feminism a Good Fit for One 'Good Muslim Boy'
Being a man, a practicing Muslim and the son of Pakistani immigrants might make Nazir Afzal an unlikely feminist to some, but that’s what the chief prosecutor for northwestern England calls himself.
6
Opinion
Can the Government Actually Do Anything About Inequality?
Listening in on the debate between political scientists and economists.
7
Science
Male Sensitivity Written in the Genes
A crucial gene on the Y chromosome, SRY, that activates male development in a human embryo is surprisingly sensitive and vulnerable to environmental factors, a study finds.
Here is the source article:
http://www.pnas.org/content/early/2013/08/29/1300828110
And the executive summery:
"
Significance
Mutations in human SRY
(sex determining region on Y chromosome) associated with somatic sex
reversal provide a model for the perturbation of a genetic
switch in organogenesis. Inherited
alleles, associated with either testicular or ovarian differentiation,
provide unique probes
of threshold biochemical properties,
defining mechanistic borders between functional and nonfunctional
transcription factors.
This study exploited two such alleles to
demonstrate that bidirectional nucleocytoplasmic trafficking
(import–export shuttling)
enables robust operation of this switch
via phosphorylation at a site external to the DNA-binding motif of the
transcription
factor. In accordance with studies of
intersexual mice, our results suggest that human SRY functions at the
edge of ambiguity."
And the abstract:
"
Abstract
Human testis determination is initiated by SRY (sex determining region on Y chromosome). Mutations in SRY
cause gonadal dysgenesis with female somatic phenotype. Two subtle
variants (V60L and I90M in the high-mobility group box)
define inherited alleles shared by an XY
sterile daughter and fertile father. Whereas specific DNA binding and
bending are
unaffected in a rat embryonic pre-Sertoli
cell line, the variants exhibited selective defects in nucleocytoplasmic
shuttling
due to impaired nuclear import (V60L;
mediated by Exportin-4) or export (I90M; mediated by chromosome region
maintenance 1).
Decreased shuttling limits nuclear
accumulation of phosphorylated (activated) SRY, in turn reducing
occupancy of DNA sites
regulating Sertoli-cell differentiation
[the testis-specific SRY-box 9 (Sox9) enhancer]. Despite distinct patterns of biochemical and cell-biological perturbations, V60L and I90M each attenuated Sox9
expression in transient transfection assays by twofold. Such
attenuation was also observed in studies of V60A, a clinical
variant associated with ovotestes and
hence ambiguity between divergent cell fates. This shared twofold
threshold is reminiscent
of autosomal syndromes of
transcription-factor haploinsufficiency, including XY sex reversal
associated with mutations in
SOX9. Our results demonstrate
that nucleocytoplasmic shuttling of SRY is necessary for robust
initiation of testicular development.
Although also characteristic of ungulate
orthologs, such shuttling is not conserved among rodents wherein
impaired nuclear
export of the high-mobility group box and
import-dependent phosphorylation are compensated by a
microsatellite-associated
transcriptional activation domain. Human
sex reversal due to subtle defects in the nucleocytoplasmic shuttling of
SRY suggests
that its transcriptional activity lies
near the edge of developmental ambiguity."
We are still waiting for the discovery of the "gay" gene.
8
9
World
Goodbye to Heidelberg
10
Business Day
Taxing Homeowners as if They Were Landlords
Bartlett is wrong.
If you want to argue you must write.
11
Technology
Why Apple Considered Splitting Its Flagship
Nick Bilton, technology columnist for The New York Times, examined some of the implications of the updates and changes coming to the iPhone line.
12
Business Day
Random House Acquires Novel by Ruth Reichl
The novel, to be released in May, is Ms. Reichl’s first, and the publisher has acquired two more.
13
U.S.
2 States Won’t Process Guards’ Same-Sex Benefits
The Texas National Guard refused to process requests from same-sex couples for benefits, while Mississippi will not issue applications from state-owned offices.
14
Business Day
Paid Vacation's Decline
A smaller share of private sector workers get paid vacation days than was the case two decades ago. But the number of days has increased for those who get them.
15
Opinion
Should the Third Year of Law School Be Cut?
Those in the field debate the value of three years of formal legal education.
16
Opinion
‘Breaking Bad’ Vitriol
A reader writes about the disturbing comments directed toward the actress Anna Gunn and her TV character.I know that the character of Characters in a drama is the responsibility of the writers.
I suspect that most viewers do not know that shows are written.
17
World
Iran Ruling In Europe Draws Anger From U.S.
The United States imposes new restrictions just as a European Union court rules that the bloc wrongly imposed sanctions against seven Iranian companies.
18
Technology
Apple Unveils Faster iPhone, and a Cheaper One, Too
The lower-cost model, the iPhone 5C (the “C” for color), comes in a plastic case and has the same features as the now-outdated iPhone 5.iPhone;
If you need a big screen get one.
19
World
Obama Delays Syria Strike to Focus on a Russian Plan
President Obama said he would pursue a “diplomatic path” on the Syria crisis even while making the moral case for punishing the country for its deadly use of chemical weapons.
20
World
Russian Proposal Could Offer Obama Escape From Bind
President Obama found himself in the odd position of relying on his Russian counterpart, Vladimir V. Putin, of all people, to bail him out of a predicament partly of his own making.
1
World
Proposal to Protect Antarctic Waters Is Scaled Back
A proposal by the United States and New Zealand to create a huge ocean reserve in Antarctic waters has been sharply reduced after opposition from Russia and other nations with large fishing industries.
2
N.Y. / Region
Strippers Are Protected by Labor Laws, Judge Says
In a class-action suit, a federal judge ruled that dancers at Rick’s Cabaret in Manhattan deserved at least the minimum wage.
3
U.S.
Michigan: Governor to Be Questioned
Gov. Rick Snyder has agreed to be questioned by union lawyers about his decision to let Detroit file for bankruptcy protection, state lawyers said.
7
Business Day
Taxing Homeowners as if They Were Landlords
8
World
Assault on Christian Town in Syria Adds to Fears Over Rebels
Maaloula has long symbolized Syria’s history of diversity and coexistence, but most of its residents have fled after fighting between rebels and government forces.
9
Business Day
Random House Acquires Novel by Ruth Reichl
11
Health
Some Fruits Are Better Than Others
New research suggests that eating blueberries, grapes, apples and grapefruit is associated with a lower risk of developing Type 2 diabetes.
13
Business Day
Paid Vacation's Decline
15
17
Health
Stem Cell Treatments Overtake Science
Clinics are popping up offering unproven treatment for a price, posing a challenge for scientists who are moving cautiously and seeking more data.
19
Technology
Apple Unveils Faster iPhone, and a Cheaper One, Too
The lower-cost model, the iPhone 5C (the “C” for color), comes in a plastic case and has the same features as the now-outdated iPhone 5.
20
No comments:
Post a Comment